Journal: Cell Genomics

Article Title: A cis -regulatory element regulates ERAP2 expression through autoimmune disease risk SNPs

doi: 10.1016/j.xgen.2023.100460

Figure Lengend Snippet:

Article Snippet: Human: Jurkat , ATCC , TIB-152TM.

Techniques: Recombinant, Western Blot, Protease Inhibitor, TaqMan SNP Genotyping Assay, Reverse Transcription, Derivative Assay, Software, Clinical Proteomics, Sequencing, HiChIP

Journal: Science Advances

Article Title: Unmasking selective path integration deficits in Alzheimer’s disease risk carriers

doi: 10.1126/sciadv.aba1394

Figure Lengend Snippet: Statistical models.

Article Snippet: The APOE SNPs were genotyped using the ABI PRISM 7700 Sequence Detector (assay ID: C_3084793_20 for rs429358 and assay ID: C_904973_10 for rs7412; Thermo Fisher Scientific, MA, USA) with a TaqMan 5′-allele discrimination Assay-By-Design method (Thermo Fisher Scientific, MA, USA).

Techniques:

Journal: Science Advances

Article Title: Unmasking selective path integration deficits in Alzheimer’s disease risk carriers

doi: 10.1126/sciadv.aba1394

Figure Lengend Snippet: ( A ) Performance (which is inversely related to drop error) is specifically impaired in risk carriers when no supportive spatial cues are available, i.e., in the PPI subtask. ( B ) Risk carriers benefit more from environmental landmarks and boundaries than controls. (A) and (B) depict results from model 1b; results from model 1a are statistically equivalent. ( C ) Incoming (but not outgoing) distance is more closely related to spatial memory performance in risk carriers than controls (model 1c). ( D ) Goal-to-landmark distance (but not goal-to-boundary distance) is more relevant in risk carriers than controls (models 2a and 2b). ( E ) Movement-to-landmark distance (but not movement-to-boundary distance) is significantly lower in risk carriers than controls (models 2c and 2d). Y axes show parameter estimates resulting from the different models; error bars, SEM; * P < 0.05, ** P < 0.01, and *** P < 0.001. Control, APOE ε3/ε3-carriers; Risk, APOE ε3/ε4-carriers; PI, path integration; BPI, boundary-supported PI; LPI, landmark-supported PI; vm, virtual meters. See also figs. S1 to S3 and tables S1 and S2.

Article Snippet: The APOE SNPs were genotyped using the ABI PRISM 7700 Sequence Detector (assay ID: C_3084793_20 for rs429358 and assay ID: C_904973_10 for rs7412; Thermo Fisher Scientific, MA, USA) with a TaqMan 5′-allele discrimination Assay-By-Design method (Thermo Fisher Scientific, MA, USA).

Techniques: Control

Journal: Science Advances

Article Title: Unmasking selective path integration deficits in Alzheimer’s disease risk carriers

doi: 10.1126/sciadv.aba1394

Figure Lengend Snippet: ( A ) EC gray matter volume predicts performance only during PI with long incoming distances (middle to right panels) and only in risk carriers (model 3b). ( B ) In younger risk carriers, EC gray matter volume predicted performance during PI trials with long incoming distances. In older risk carriers, EC gray matter volume predicted performance during the majority of all trials (model 3b). The young group comprises subjects aged 18 to 28 years; the older group contains subjects aged 53 to 75 years (see age histogram in fig. S1C). As the models contained two continuous predictors, one of them (incoming distance) was discretized into quintiles for post hoc tests and graphical depiction. Thicker lines mark slopes that are significantly different from zero. Y axes show parameter estimates resulting from the different models; shaded areas, SEM. Control, APOE ε3/ε3-carriers; Risk, APOE ε3/ε4-carriers; % volume, percent of whole-brain volume. See also fig. S1 and tables S1 and S3.

Article Snippet: The APOE SNPs were genotyped using the ABI PRISM 7700 Sequence Detector (assay ID: C_3084793_20 for rs429358 and assay ID: C_904973_10 for rs7412; Thermo Fisher Scientific, MA, USA) with a TaqMan 5′-allele discrimination Assay-By-Design method (Thermo Fisher Scientific, MA, USA).

Techniques: Control

Journal: Science Advances

Article Title: Unmasking selective path integration deficits in Alzheimer’s disease risk carriers

doi: 10.1126/sciadv.aba1394

Figure Lengend Snippet: The younger age group comprises subjects aged 18 to 41 ( n = 163), and the older age group comprises subjects aged 42 to 75 ( n = 104). ( A ) Performance (which is inversely related to drop error) is specifically impaired in older risk carriers when no supportive spatial cues are available, i.e., in the PPI subtask. ( B ) In older participants, risk carriers benefit more from environmental landmarks and boundaries than controls. (A) and (B) depict results from model 1b; results from model 1a are statistically equivalent. ( C ) In both age groups, neither incoming nor outgoing distance is more closely related to spatial memory performance in risk carriers than controls. ( D ) In the younger age group, goal-to-boundary distance is more relevant in risk carriers than in controls (models 2a and 2b). ( E ) In younger participants, movement-to-landmark distance (but not movement-to-boundary distance) is significantly lower in risk carriers than in controls (models 2c and 2d). Y axes show parameter estimates resulting from the different models; error bars, SEM. + P < 0.10, * P < 0.05, ** P < 0.01, and *** P < 0.001. Control, APOE ε3/ε3-carriers; Risk, APOE ε3/ε4-carriers. See also figs. S1 to S3 and tables S1, S2, and S4.

Article Snippet: The APOE SNPs were genotyped using the ABI PRISM 7700 Sequence Detector (assay ID: C_3084793_20 for rs429358 and assay ID: C_904973_10 for rs7412; Thermo Fisher Scientific, MA, USA) with a TaqMan 5′-allele discrimination Assay-By-Design method (Thermo Fisher Scientific, MA, USA).

Techniques: Control